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Canada Cancer Research

Top 5 Globally in Precision Medicine & AI Innovation

35x

Stem Cell Expansion

UM171 breakthrough

Top 5

Global Cancer Research Rank

Princess Margaret #1 in Canada

10x

Faster Drug Discovery

AI-powered design

Major Research Breakthroughs

UM171 Revolutionary Cell Therapy Discovery

2022-2024

Canadian scientists discovered UM171, a small molecule that expands blood stem cells by 35-fold, revolutionizing bone marrow transplants and CAR-T therapy production.

Institute for Research in Immunology and Cancer (IRIC), Université de Montréal

Impact:

Making stem cell transplants possible for patients without perfect donor matches

AI-Powered Drug Design Platform

2023-2024

Canadian researchers developed AI systems that design new cancer drugs in weeks instead of years, identifying compounds that big pharma missed.

University of Toronto, Vector Institute

Impact:

Accelerating cancer drug discovery by 10x

Actinium-225 Radioisotope Therapy

2023-2024

Canada leads production of Actinium-225, a powerful radioactive isotope used in targeted alpha therapy for metastatic cancers resistant to other treatments.

TRIUMF (Canada's particle accelerator centre)

Impact:

Destroying cancer cells with minimal damage to healthy tissue

First-in-Human Oncolytic Virus Trials

2020-2024

Canadian biotech companies pioneered using engineered viruses that selectively infect and kill cancer cells while sparing normal tissue.

Ottawa Hospital Research Institute

Impact:

Harnessing viruses to fight cancer

Liquid Biopsy for Early Detection

2023-2024

Canadian researchers developed blood tests that detect cancer DNA fragments months before tumors appear on imaging, enabling ultra-early intervention.

BC Cancer, Princess Margaret Cancer Centre

Impact:

Catching cancer at its most curable stage

Universal Healthcare Cancer Outcomes Research

Ongoing

Canada's single-payer system provides unique population-level data on cancer treatment effectiveness, informing global best practices.

Canadian Partnership Against Cancer

Impact:

Proving which treatments actually work in real-world populations

Leading Research Institutions

Princess Margaret Cancer Centre

Toronto, Ontario

One of the world's top 5 cancer research centers. Leading AI drug discovery, liquid biopsy, and proton therapy. Affiliated with University of Toronto.

Key Specialties:

AI Drug Discovery
Liquid Biopsy
Proton Therapy
Precision Medicine

BC Cancer

Vancouver, British Columbia

Western Canada's leading cancer center. Pioneer in personalized oncology, genomic medicine, and population cancer research.

Key Specialties:

Genomic Medicine
Personalized Oncology
Population Health

Institut de Recherche en Immunologie et en Cancérologie (IRIC)

Montreal, Quebec

World-renowned for UM171 discovery. Leading research in cancer immunology and cellular therapy innovation.

Key Specialties:

Stem Cell Research
CAR-T Innovation
Cancer Immunology
Active Clinical Trials in Canada

Canada welcomes international patients to cutting-edge clinical trials

UM171 Enhanced CAR-T Therapy

Phase 2

Using UM171 to create more powerful CAR-T cells that persist longer and work against solid tumors.

IRIC, Princess Margaret Cancer Centre
Active recruitment

Actinium-225 Targeted Alpha Therapy

Phase 2

Testing Actinium-225 radioisotope therapy for metastatic prostate, neuroendocrine, and other cancers resistant to standard treatments.

TRIUMF, BC Cancer
Active recruitment

AI-Designed Cancer Drug (First-in-Human)

Phase 1

First human trial of a cancer drug designed entirely by artificial intelligence for specific genetic mutations.

Princess Margaret Cancer Centre
Active recruitment

Liquid Biopsy Early Detection Program

Population Study

Nationwide study using liquid biopsies to detect cancer recurrence early in high-risk patients.

BC Cancer, Canadian Partnership Against Cancer
Ongoing enrollment

Want to learn about more Canadian clinical trials? Search our database or contact our team.

Clinical Trials in Canada

Registry-listed trials for Canada currently tracked in our database, sourced from public trial registries.

(CHRONO-RCC) Time-of-day-Dependent Administration of Dual Immune Check Point Inhibitors (ICI) in Advanced Kidney Cancer

Phase III
Not yet recruiting
NCT07338981
View registry record

(CHRONO-RCC) Time-of-day-Dependent Administration of Dual Immune Check Point Inhibitors (ICI) in Advanced Kidney Cancer

Phase III
Not yet recruiting
NCT07338981
View registry record

(CHRONO-RCC) Time-of-day-Dependent Administration of Dual Immune Check Point Inhibitors (ICI) in Advanced Kidney Cancer

Phase III
Not yet recruiting
NCT07338981
View registry record

Phase II Study of Subcutaneous Blinatumomab Plus Ponatinib for BCR-ABL Positive B-Cell Acute Lymphoblastic Leukemia

Phase II
Not yet recruiting
NCT07301424
View registry record

Phase II Study of Subcutaneous Blinatumomab Plus Ponatinib for BCR-ABL Positive B-Cell Acute Lymphoblastic Leukemia

Phase II
Not yet recruiting
NCT07301424
View registry record

Phase II Study of Subcutaneous Blinatumomab Plus Ponatinib for BCR-ABL Positive B-Cell Acute Lymphoblastic Leukemia

Phase II
Not yet recruiting
NCT07301424
View registry record

Phase II Study of Subcutaneous Blinatumomab Plus Ponatinib for BCR-ABL Positive B-Cell Acute Lymphoblastic Leukemia

Phase II
Not yet recruiting
NCT07301424
View registry record

Outside the Cage (OTC) Robotic Esophagectomy , Single Center Phase I Trial

Phase I
Not yet recruiting
NCT06735638
View registry record

Outside the Cage (OTC) Robotic Esophagectomy , Single Center Phase I Trial

Phase I
Not yet recruiting
NCT06735638
View registry record

RESTAGE (REpurposing STAtins to Improve Outcomes in GastroEsophageal Cancer) Trial: A Phase II Randomized Open-Label Trial of Perioperative Simvastatin Plus Standard-of-Care Systemic Therapy in Gastroesophageal Adenocarcinoma

Phase II
Not yet recruiting
NCT07625930
View registry record

Outside the Cage (OTC) Robotic Esophagectomy , Single Center Phase I Trial

Phase I
Not yet recruiting
NCT06735638
View registry record

RESTAGE (REpurposing STAtins to Improve Outcomes in GastroEsophageal Cancer) Trial: A Phase II Randomized Open-Label Trial of Perioperative Simvastatin Plus Standard-of-Care Systemic Therapy in Gastroesophageal Adenocarcinoma

Phase II
Not yet recruiting
NCT07625930
View registry record

Latest Research Ecosystem Developments

Canada — Canada's cancer research ecosystem is experiencing a period of significant growth, marked by major federal investments in precision oncology and the launch of a new national program to support independent, investigator-initiated clinical trials.

Updated October 11, 2026

Government of Canada Invests $80 Million in Precision Oncology

In September 2026, the federal government announced an $80-million investment to support Phase 2 of the Marathon of Hope Cancer Centres Network, which will be matched by the Terry Fox Research Institute and partners to total $160 million for expanding equitable access to precision cancer care.

Government of Canada

Launch of National Program for Investigator-Initiated Clinical Trials

In April 2026, the Cancer Research Society, in partnership with the Canadian Cancer Society and the Terry Fox Research Institute, launched a $25-million national program to fund high-impact clinical trials that are not sponsored by the pharmaceutical industry.

Cancer Research Society

Expansion of Cell Therapy Research

In July 2026, the Canadian Cancer Trials Group (CCTG) opened its first two investigator-led cell therapy trials in Canada, marking a new milestone in the country's clinical research capabilities.

BC Cancer Research Centre

New Facility for Canada's Largest Cancer Tumour Bank

The CCTG established a new home for its Tumour Tissue Data Repository (TTDR), which provides researchers across Canada with enhanced access to high-quality research materials from over 300,000 samples collected from more than 200 trials.

Canadian Cancer Trials Group

Groundbreaking Colon Cancer Clinical Trial Results

A 2025 clinical trial demonstrated that colon cancer patients who participated in a structured physical activity program experienced a 28% lower risk of cancer recurrence and a 37% lower risk of death.

Canadian Cancer Society

This section is refreshed on a recurring schedule. Entries are AI-assisted research signals organized from public oncology sources and should be verified against the original sources. Information is educational and does not constitute medical advice.

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